BiologicalActivity
PotentDYRK1Binhibitor(IC50valuesare17,88and1890nMforDYRK1B,DYRK1AandDYRK2respectively).InhibitsDYRK1B-inducedGiphasecellcyclearrestinPanc-1cellsinvitro.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofAZ191isreviewedonthechemicalprobeswebsite.
CompoundLibraries
AZ191isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 429.52 |
| Formula | C24H27N7O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1594092-37-1 |
| PubChemID | 72716071 |
| InChIKey | ZYVXTMKTGDARKR-UHFFFAOYSA-N |
| Smiles | CN2C=C(C3=CC=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=N3)C1=CC=NC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.95 | 100 | |
| ethanol | 8.59 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight429.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.33mL | 11.64mL | 23.28mL |
| 5mM | 0.47mL | 2.33mL | 4.66mL |
| 10mM | 0.23mL | 1.16mL | 2.33mL |
| 50mM | 0.05mL | 0.23mL | 0.47mL |
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ProductDatasheets
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