Tocris/AZ Dyrk1B 33/5632/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/AZ Dyrk1B 33/5632/10/10 mg

Tocris/AZ Dyrk1B 33/5632/10/10 mg

商品编号： 5632/10

品牌： Tocris Bioscience

市场价： ¥5180.00

美元价： 3108.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectiveDyrk1Bkinaseinhibitor

ChemicalName:3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveATP-competitiveDyrk1Bkinaseinhibitor(IC₅₀=7nM);displaysdistinctcellulareffectswhencomparedtoDYRK1BknockdownthroughsiRNA.Demonstratescellularinvitroactivity(IC₅₀=194nM).ExhibitsbetterselectivitythanAZ191(Cat.No5232);displaysnooff-targeteffectsagainstapanelof124kinasestested(nokinasewasinhibitedabove50%at1μM).

TechnicalData

M.Wt	300.36
Formula	C₁₉H₁₆N₄
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1679330-37-0
PubChemID	118735338
InChIKey	CZCUSHJQJWKYTD-UHFFFAOYSA-N
Smiles	CC1=NC=CC(C2=CN(CC3=CC=CC=C3)C4=CN=CC=C42)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	30.04	100
	DMSO	30.04	100
	ethanol	30.04	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight300.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.33mL	16.65mL	33.29mL
5mM	0.67mL	3.33mL	6.66mL
10mM	0.33mL	1.66mL	3.33mL
50mM	0.07mL	0.33mL	0.67mL

ProductDatasheets

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