BiologicalActivity
Potentinhibitorofcyclin-dependentkinase(cdk)1,2and9(IC50valuesare16,6and20nMrespectively).Exhibitsantiproliferativeactivityinhumantumorcelllines.BlockscellcyclingatG2-M,SandG1phases;reducestheproportionofactivelycyclingcellsinvivo.
LicensingInformation
SoldwiththepermissionofAstraZenecaUKLtd.
CompoundLibraries
AZD5438isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 371.46 |
| Formula | C18H21N5O2S |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 602306-29-6 |
| PubChemID | 16747683 |
| InChIKey | WJRRGYBTGDJBFX-UHFFFAOYSA-N |
| Smiles | CS(C(C=C3)=CC=C3NC1=NC(C2=CN=C(C)N2C(C)C)=CC=N1)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.15 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight371.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.46mL | 26.92mL |
| 5mM | 0.54mL | 2.69mL | 5.38mL |
| 10mM | 0.27mL | 1.35mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
MolarityCalculator
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ProductDatasheets
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