BiologicalActivity
PotentandselectiveinhibitorofPI3-kinaseβ(PI3-Kβ)(IC50valuesare0.69,13.6,47.8and136nMforPI3-Kβ,PI3-Kδ,PI3-KγandPI3-Kα,respectively).SelectivelyinhibitsinvivogrowthofthePTEN-deficienttumorxenograftsHCC70andPC3.Alsoexhibitsantithromboticactivity.
LicensingInformation
SoldwiththepermissionofAstraZenecaUKLtd.
CompoundLibraries
AZD6482isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 408.45 |
| Formula | C22H24N4O4 |
| Storage | Storeat-20°C |
| Purity | ≥98% |
| CASNumber | 1173900-33-8 |
| PubChemID | 44137675 |
| InChIKey | IRTDIKMSKMREGO-OAHLLOKOSA-N |
| Smiles | OC(C1=C(N[C@@H](C2=CC(C)=CN3C2=NC(N4CCOCC4)=CC3=O)C)C=CC=C1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 4.08 | 10 | |
| DMSO | 40.84 | 100 | |
| ethanol | 8.17 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight408.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.45mL | 12.24mL | 24.48mL |
| 5mM | 0.49mL | 2.45mL | 4.9mL |
| 10mM | 0.24mL | 1.22mL | 2.45mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
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ProductDatasheets
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