BiologicalActivity
PotentandselectiveATP-competitiveinhibitorofChk1andChk2(IC50valesare5nMforbothkinases);displaysatleast>10foldselectivityoverapanelof164kinases.PotentiatescytotoxicityofDNA-damagingagents.Activeinvivo.
LicensingInformation
SoldforresearchpurposesunderagreementfromAstraZeneca
CompoundLibraries
AZD7762hydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 398.88 |
| Formula | C17H19FN4O2S.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1246094-78-9 |
| PubChemID | 56972142 |
| InChIKey | WFZBLOIXZRZEDG-YDALLXLXSA-N |
| Smiles | FC1=CC=CC(C2=CC(NC(N)=O)=C(C(N[C@@H]3CNCCC3)=O)S2)=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.89 | 100 | |
| water | 39.89 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight398.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.51mL | 12.54mL | 25.07mL |
| 5mM | 0.5mL | 2.51mL | 5.01mL |
| 10mM | 0.25mL | 1.25mL | 2.51mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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ProductDatasheets
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