Biological Activity
A potent, selective GABAB receptor antagonist (IC50 = 4 nM).
Licensing Information
Sold with the permission of Novartis Pharma AG
Compound Libraries
CGP 54626 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 444.76 |
| Formula | C18H28Cl2NO3P.HCl |
| Storage | Store at RT |
| Purity | ≥96% |
| CAS Number | 149184-21-4 |
| PubChem ID | 197583 |
| InChI Key | ZQCFHOVIXCJPLE-LINSIKMZSA-N |
| Smiles | OP(CC1CCCCC1)(C[C@@H](O)CN[C@@H](C)C2=CC(Cl)=C(Cl)C=C2)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 22.24 | 50 |
| ethanol | 4.45 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 444.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 2.25 mL | 11.24 mL | 22.48 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.5 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.25 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Brugger et al (1993) The action of new potent GABAB receptor antagonists in the hemisected spinal cord preparation of the rat. Eur.J.Pharmacol. 235 153 PMID: 8390938
Kaupmann et al (1998) GABAB-receptor subtypes assemble into functional heteromeric complexes. Nature 396 683 PMID: 9872317
Froestl et al (1996) Potent, orally active GABAB receptor antagonists. Pharmacol.Rev.Comm. 8 127 PMID:
Keywords: CGP 54626 hydrochloride, supplier, Potent, selective, GABAB, antagonists, Receptors, CGP54626, hydrochloride, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience
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