Biological Activity
Promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.
Compound Libraries
KY 02111 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 376.86 |
| Formula | C18H17ClN2O3S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1118807-13-8 |
| PubChem ID | 8582409 |
| InChI Key | LXFKEVQQSKQXPR-UHFFFAOYSA-N |
| Smiles | O=C(CCC3=CC=C(OC)C(OC)=C3)NC2=NC1=CC=C(Cl)C=C1S2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 18.84 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 376.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 2.65 mL | 13.27 mL | 26.54 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.31 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution. Reconstitution CalculatorReconstitution Calculator
Dilution CalculatorDilution Calculator
Calculate the dilution required to prepare a stock solution.Product Datasheets
Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Minami et al (2012) A small molecule that promotes cardiac differentiation of humam pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2 1448 PMID: 23103164
Keywords: KY 02111, supplier, KY02111, stem, cell, differentiation, cardiomyocytes, human, iPSCs, ESCs, Wnt, signaling, pathway, inhibits, inhibitors, Other, Wnt, Signaling, Cardiomyocyte, Stem, Cells, ESCs, and, iPSC, Cardiomyocyte, Stem, Cells, Tocris Bioscience
本文链接： http://tocris.immuno-online.com/view-1466184943.html
