Biological Activity
Photoswitchable TRPV1 channel blocker (IC50 = 3.1 μM). Acts as an antagonist in trans conformation during voltage gated activation. Also acts as an antagonist in the cis formation during capsaicin-induced TRPV1 currents. Switches conformation from cis to trans at 440 nm and trans to cis at 360 nm. Allows photoswitchable antagonist and an agonist to be applied at the same time.
Technical Data
| M. Wt | 514.56 |
| Formula | C26H25F3N4O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1459809-09-6 |
| PubChem ID | 121513863 |
| InChI Key | COPZFJSJZPCWFD-UHFFFAOYSA-N |
| Smiles | S=C(NCCC3=CC=C(/N=N/C4=CC=C(C(F)(F)F)C=C4)C=C3)N(CCC2)CC1=C2C=C(O)C(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 51.46 | 100 |
| water | 10.29 | 20mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 514.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 1.94 mL | 9.72 mL | 19.43 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.89 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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Certificate of Analysis / Product DatasheetSafety DatasheetSelect another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Stein et al (2013) Optical control of TRPV1 channels. Angew.Chem.Int.Ed.Engl. 52 9845 PMID: 23873837
Keywords: AC 4, supplier, Photoswitchable, TRPV1, channel, blockers, transient, receptor, potential, vanilloids, ligands, Photoswitchable, Ligands, TRPV, Photoswitchable, Ligands, Tocris Bioscience
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